The last RISE Workshop took place at F. Hoffmann-La Roche’s headquarters in Basel on June 4th 2009. The workshop was concerned with the strategic management of innovation. In particular, it addressed the challenges of innovation in the pharmaceutical context and how managers cope with these challenges. First, Paul Nagagaki, Head of Group Research Strategy of Roche presented insights on Roche’s particular challenges with investments in new technologies and approaches. Second, Florian Bertram of RISE presented the findings of his dissertation on how managers create and establish new and uncertain opportunities.